2008. x�S�*�*T0T0 B�����i������ yS& Development of a SNP genotyping panel for genetic monitoring of the laboratory mouse. Genes Dev 7(3):454-67, Moy SS; Nadler JJ; Young NB; Perez A; Holloway LP; Barbaro RP; Barbaro JR; Wilson LM; Threadgill DW; Lauder JM; Magnuson TR; Crawley JN. endobj These Mighty Mice have twice the muscle mass of normal mice that possess the gene for producing myostatin. Unstable FoxP3+ T regulatory cells in NZW mice. Differential maintenance and frequency-dependent tuning of LTP at hippocampal synapses of specific strains of inbred mice. Hear Res 93(1-2):181-7, Ewart SL; Kuperman D; Schadt E; Tankersley C; Grupe A; Shubitowski DM; Peltz G; Wills-Karp M. 2000. Many inbred mouse strains have an exon 9 to 11 deletion, resulting in a null allele and susceptibility to myxoviruses, including: A/J, ABP/Le, AKR/J, AU/SsJ, BALB/cJ, BDP/J, BUB/BnJ, C3H/HeJ, C57BL/6J, C57BL/10J, C57BL/KsJ, C57L/J, C58/J, DA/HuSn, DBA/2J, FSB/GnEi, FVB/NJ, LIS/A, LP/J, MA/MyJ, MAS/A, NZB/BINJ, P/J, PL/J, RIIIS/J, RF/J, SEA/GnJ, SEC1/ReJ, SJL/J, ST/bJ, TS1/A, TW1/A. Am J Respir Cell Mol Biol 23(4):537-45, Freeman HC; Hugill A; Dear NT; Ashcroft FM; Cox RD. 2020-02-18T09:32:19-08:00 This allele contains a stretch of 17,814 bp missing between exons 6 and 12. Genetic background determines metabolic phenotypes in the mouse. <>stream They are the most widely used and best-selling mouse strain, due to the availability of congenic strains, easy breeding, and robustness. Atherosclerosis susceptibility differences among progenitors of recombinant inbred strains of mice. C57BL/6J (000664) mice tend to have more pups with hydrocephaly than do other strains. x�%�A�@�}O�(��'.�r�^���� Bone 18(5):397-403, Beamer WG; Shultz KL; Churchill GA; Frankel WN; Baylink DJ; Rosen CJ; Donahue LR. 2009. Nature 352(6336):621-4. 2006. Deletion of Nicotinamide Nucleotide Transhydrogenase: A New Quantitive Trait Locus Accounting for Glucose Intolerance in C57BL/6J Mice. Genes Dev 8(4):481-90, Bultman SJ; Michaud EJ; Woychik RP. Distortion product otoacoustic emissions in the C57BL/6J mouse model of age-related hearing loss. 2000. <>>>/BBox[0 0 585 783]/Length 114>>stream G3. Genetic complementation tests have shown allelism between the mdfw (modifier of deaf waddler) locus and the ahl locus. endobj Mamm Genome 19(5):318-31, Drake TA; Schadt E; Hannani K; Kabo JM; Krass K; Colinayo V; Greaser LE 3rd; Goldin J; Lusis AJ. 1991. Mamm Genome. … Macrophages from this strain are resistant to the effects of anthrax lethal toxin.Study-ready aged C57BL/6J males and females between 25 - 90 weeks of age available for order. The Jackson Laboratory (JAX)® advocates adherence to the mouse strain nomenclature guidelines as described by the International Committee on Standardized Genetic Nomenclature for Mice. <>stream J Lipid Res 31(3):467-77, Kirk EA; Moe GL; Caldwell MT; Lernmark JA; Wilson DL; LeBoeuf RC. endobj Am J Clin Nutr 62(2):458S-462S, Paigen B; Ishida BY; Verstuyft J; Winters RB; Albee D. 1990. <>stream C57BL/6J mice also develop severe and progressive hearing loss later in life, with the disruption of both outer and inner hair cells, due to the Cdh23Ahl allele. Diabetes 52(8):1958-66, Sarna JR; Dyck RH; Whishaw IQ. 1986. The wild-type C variant, coding for proline, is found in 129P2/OlaHsd, 129S1/SvImJ, 129S5SvEvBrd, A/J, BALB/c, CAST/EiJ ,NZW, LP/J, NOD/ShiLtJ, PWK/PhJ, WSB/EiJ, Mus caroli, M. spretus, M. musculus, and M. poschiavinus. All mice were maintained in our mouse colony at the University of Pennsylvania Medical Center. Proc Natl Acad Sci U S A 91(12):5667-71, Welkos SL; Keener TJ; Gibbs PH. <>stream Genetic variability in adult bone density among inbred strains of mice. 1�^���|7�PE$HG�cD�d�ҥ8C&���GӦmйM���u A{l��0�^aU[���"��֔���~%��6>��m Arteriosclerosis 10(2):316-23, Parekh PI; Petro AE; Tiller JM; Feinglos MN; Surwit RS. This gene locus controls recovery from viremia and leukemia induced by Friend virus (FV). The Jackson Laboratory, founded by Clarence Cook Little, who produced the inbred mouse strain C57BL, among others, is the most cited experimental murine animal supplier. • J: Labor Code The Jackson Laboratory Dieser Stamm wurde nicht durch Rückkreuzungen, sondern durch Verpaaren von drei individuellen congenen Stämmen erzeugt, die die varianten Allele bereits auf einem C57BL/6J genetischen Hintergrund trugen: B6.C-Igh a immunoglobulin heavy chain complex B6.PL-Thy1 a thymus cell antigen 1, theta 3 0 obj Science 342(6165):1508-12, McKhann GM 2nd; Wenzel HJ; Robbins CA; Sosunov AA; Schwartzkroin PA. 2003. NSG™ Mice Pub Alert (Monthly): Course and Workshop Announcements (Monthly): Research Roundup (Biweekly): Cancer: Immunology, Inflammation & Autoimmunity: Immuno-oncology: Infect C57BL/6J mice are resistant to audiogenic seizures, have a relatively low bone density, and develop age related hearing loss. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Science 345(6195):455-9, Jackson IL; Zhang Y; Bentzen SM; Hu J; Zhang A; Vujaskovic Z. 2019 Dec;30(11-12):353-361. Oxidative damage-induced inflammation initiates age-related macular degeneration. These mice are on a congenic C57/BL genetic background. xmp.did:C6AD69875588E0119B65E91AE40D8D8E Diabetologia 48(4):675-86, Waterston RH; Lindblad-Toh K; Birney E; Rogers J; Abril JF; Agarwal P; Agarwala R; Ainscough R; Alexandersson M; An P; Antonarakis SE; Attwood J; Baertsch R; Bailey J; Barlow K; Beck S; Berry E; Birren B; Bloom T; Bork P; Botcherby M; Bray N; Brent MR; Brown DG; Brown SD; Bult C; Burton J; Butler J; Campbell RD; Carninci P; Cawley S; Chiaromonte F; Chinwalla AT; Church DM; Clamp M; Clee C; Collins FS; Cook LL; Copley RR; Coulson A; Couronne O; Cuff J; Curwen V; Cutts T; Daly M; David R; Davies J; Delehaun. <>>>/BBox[0 0 585 783]/Length 114>>stream x�%�A�@�}O�(��'.�r�^���� Article Title: Role of IRAK-M in Alcohol Induced Liver Injury Article Snippet: ..We used C57B/L6 mice from the Jackson Laboratory as controls, and these mice were used to backcross the IRAK-M−/− mice. Watch Video. The Jackson Laboratory (JAX)® advocates adherence to the mouse strain nomenclature guidelines as described by the International Committee on Standardized Genetic Nomenclature for Mice. Twenty-seven strains classified with ahl and carrying the 753A allele include: CD-1, RBF/DnJ, PL/J, AKR/J, RF/J, BALB/cBy, A/WySnJ, P/J, SENCARA/PtJ, DBA/1J, ALS/LtJ, C58/J, C57BLKS/J, 129P1/ReJ, C57BR/cd, SKH2/J, BUB/Bn, MA/MyJ, LP/J, 129X1/SvJ, NOR/LtJ, A/J, C57BL/6, NOD/LtJ, DBA/2J, ALR/LtJ, C57L/J. 2016. 1991. 2000. Little in 1921, from a mating of Miss Abby Lathrop’s stock that also gave rise to strains C57BR and C57L. In vitro analysis demonstrates that the resulting truncated protein, which lacks several conserved C-terminal motifs, has less than 1% enzyme activity when compared to control C3H/HeJ mice. <>>>/BBox[0 0 585 783]/Length 114>>stream Hyper- and hypo-responsiveness to dietary fat and cholesterol among inbred mice: searching for level and variability genes. xmp.id:3fc93184-1b25-7b4b-bee8-5451dbe7f73b B6.Cg- Kit W-44J Gpi1 a : A mouse strain with the genetic background of C57BL/6, but where the donor strain is mixed, the Kit allele originating from C3H/HeJ and the Gpi1 allele originating from CAST/Ei. The Jackson Laboratory’s Mission 4 Performing Research Investigating genetics and biology of human disease Providing Resources JAX® Mice Clinical & Research Services, bioinformatics data, technical publications and more… Inbred mouse strains are maintained through sibling (sister x brother) matings; no genotyping required. Ribosome stalling induced by mutation of a CNS-specific tRNA causes neurodegeneration. Resistance is not dependent on presence of the thymus and is not abolished by immunosuppression or by inhibitors of macrophage function (J:5735, J:5478, J:5645). Nat Commun 7:13180, Vrieling H; Duhl DM; Millar SE; Miller KA; Barsh GS. Holth JK et al used Jackson Laboratory B6C3F1/J mice (#100010) and B6C3 tau P301S mice (# 008169) to study mouse brain interstitial fluid tau level during … converted <>stream Hybrid mice, such as B6C3, a cross between C57BL/6J females (B6) and C3H/HeJ males (C3), is gaining popularity. C57BL/6J mice fed an atherogenic diet (1.25% cholesterol, 0.5% cholic acid and 15% fat) for 14 weeks develop lesions in the range of 4500 to 8000 um2 atherosclerotic aortic lesions/aortic cross-section. The laboratory mouse or lab mouse is a small mammal of the order Rodentia which is bred and used for scientific research.Laboratory mice are usually of the species Mus musculus.They are the most commonly used mammalian research model and are used for research in genetics, psychology, medicine and other scientific disciplines. Behav Brain Res 176(1):4-20, Nguyen PV; Duffy SN; Young JZ. 20 0 obj endobj Resistance to infection with two tick-borne viruses, Thogoto virus (J:8273) and Dhori virus (J:27760), is also conferred by Mx1r. 5 SNP differences have been identified that distinguish C57BL/6J from C57BL/6ByJ and C57BL/6NJ. They are available as JAX MMRRC Stock# 034832 (formerly as Jackson Lab Stock# 005864). This model was created by microinjecting the human APP 695 gene containing the double mutation K670N, M671L into B6SJLF2 zygotes using a hamster prion protein cosmid vector. Hear Res 112(1-2):216-34, Petkov PM; Ding Y; Cassell MA; Zhang W; Wagner G; Sargent EE; Asquith S; Crew V; Johnson KA; Robinson P; Scott VE; Wiles MV. xmp.did:30ddafd1-3476-2545-95af-65bcea7db857 2000. The hybrid mice are heterozygous genetically and tend to serve as a background for some deleterious mutations. Most inbred strains, including C57BL/6J, C3H/HeJ, and BALB/cJ, carry an influenza susceptible Mx1s1 allele which produces mRNA lacking exons 9, 10, and 11 of the Mx1r allele. Th ese techniques have been developed and used by Th e Jackson Laboratory for over 75 years. endobj Genetics of age-related hearing loss in mice. Sexes: Sexes of the same strain may be combined to reach minimum quantity levels to receive the volume pricing This mutation is not found in C57BL/6JEi, C57BL/6N, C57BL/6NJ, C57BL/6ByJ, C57BL/10J, C57L/J, or C58/J (Toye AA, et al, Diabetologia, 2005). Mice. 2008. APOE was humanized by replacing mouse ApoE exons 2, 3, and … C57BL/6J mice are also commonly used in the production of transgenic mice. Terms are granted by individual review and stated on the customer invoice(s) and account statement. Researchers from The Jackson Laboratory sent 40 mice to the ISS National Lab, including some “Mighty Mice” that lack the gene for producing the growth factor myostatin. 11 0 obj PMID: 11591219 C57BL/6J Genomic DNA from The Jackson Laboratory Wild-type Snca C57BL/6NCrl Mice from Charles River, Margate, UK Wild-type Snca Nuclear localization is necessary for anti-influenza virus activity (J:1417), but mutations induced in Mx1 showed that nuclear position was not sufficient for the effect; mutations in several domains can cause its loss (J:11840). J Immunol 129(4):1530-3, Smith BK; Andrews PK; West DB. <>>>/BBox[0 0 585 783]/Length 114>>stream This is a dominant trait. Colonies of Laboratory Mice A Jackson Laboratory Resource Manual This manual describes breeding strategies and techniques for maintaining colonies of laboratory mice. Mature protein was not detected in these mutants. A G to A conversion within a cryptic splice site results in the preferential incorporation of a pseudo-exon, containing an in-frame stop codon as the second codon, into the transcript. Additionally, an intronic point deletion in Gabra2, which arose sometime between the early 1970's and 1990's, results in decreased transcript and protein expression of this chloride channel component in the brain. endobj Reversal of diet-induced obesity and diabetes in C57BL/6J mice. C57BL/6J is the most widely used inbred strain and the first to have its genome sequenced. endstream The following phenotype relates to a compound genotype created using this strain. x�+� � | Strain background had a significant effect on the onset and severity of ocular phenotypes in Lmx1b V265D/ + mutant mice. A comparative study between C57BL/6J and CBA mice. Cheers and McKenzie found C57BL/6J resistant to listeriosis. Shipment: All shipping destinations qualify. B6.Rag1-/- mice displayed nearly identical blood pressure increases monitored via radiotelemetry and hypertensive end-organ damage in response to different doses of Ang II and different levels of salt intake (0.02%, 0.3%, and 3% NaCl diet). They are also susceptible to diet-induced obesity, type 2 diabetes, and atherosclerosis. 1994. Readily available in any quantity needed. x�+� � | Come back soon for exciting changes. endstream 1�^���|7�PE$HG�cD�d�ҥ8C&���GӦmйM���u A{l��0�^aU[���"��֔���~%��6>��m PMID: 11591219 C57BL/6J Genomic DNA from The Jackson Laboratory Wild-type Snca C57BL/6NCrl Mice from Charles River, Margate, UK Wild-type Snca Therefore, we cannot guarantee a strain's phenotype will meet all expectations. A genetic and physiological study of impaired glucose homeostasis control in C57BL/6J mice. The mutation lies within a C-terminal cytoplasmic domain homologous with the TNFR 1-death domain and with an SH3 binding protein. Availability: Available through The Jackson Laboratory… This change would prevent the 43 amino acid extension of mRNA translation predicted for the DBA/2J allele and account for the smaller size of the peptide produced by this allele (95 kDa vs 104 kDa for the DBA/2J allele). 2020-02-06T13:32:01+05:30 Mol Microbiol 29(2):581-91, Rohan RM; Fernandez A; Udagawa T; Yuan J; D'Amato RJ. An efficient SNP system for mouse genome scanning and elucidating strain relationships. <>>>/BBox[0 0 585 783]/Length 114>>stream Quantities: Volume pricing is automatically applied when a minimum quantity per strain for a shipment is reached C57BL/6, often referred to as "C57 black 6", "C57" or "black 6", is a common inbred strain of laboratory mouse.. Adobe InDesign CC 2015 (Windows) To The Jackson Laboratory in 1948 from Hall. To Hall in 1948 from The Jackson Laboratory. It is commonly used as a general purpose strain and background strain for the generation of congenics carrying both spontaneous and induced mutations. Exp Anim 58(2):141-9, Miller MW; Duhl DM; Vrieling H; Cordes SP; Ollmann MM; Winkes BM; Barsh GS. View credits, reviews, tracks and shop for the 1983 Gatefold Vinyl release of The Final Cut on Discogs. Mouse behavioral tasks relevant to autism: phenotypes of 10 inbred strains. 4 The Jackson Laboratory Breeding performance of laboratory mice can be affected by many factors, including the following: • Birth defects in the pups. 1998. PCR sequencing of cDNA revealed ten nucleotide differences between the coding sequences of the DBA/2J and C57BL/6J receptors. 12 0 obj 1992. Aged B6 Mice: Considerations, Applications, and Best Practices Technical Information Services May 18, 2017 Aged C57BL/6J mouse at 63 weeks . Mice Pup Appearance by Age. ZERO BIAS - scores, article reviews, protocol conditions and more 23 0 obj Five of the ten differences would cause amino acid changes. Allergen-induced airway disease is mouse strain dependent. uuid:e46a0396-ed28-431b-b0a8-ff16e0f3881c C57BL/6J is the most widely used inbred strain. The same cross gave rise to the C57L and C57BR strains. 1 0 obj Attention to Background Strain Is Essential for Metabolic Research: C57BL/6 and the International Knockout Mouse Consortium. %���� Other Resources endobj 2009. Twelve SNPs were found informative to discriminate among the mouse strains considered. 2004. This strain is available from some international Charles River (CR) breeding facilities in Japan and/or Europe. Interferon is induced by viral infection and in turn induces the Mx protein (J:7703). The variation in aortic lesions found among various inbred strains has led to the identification of the existence of eight genes affecting atherosclerosis, Ath1 to Ath8. 1994. It is because of the contributions of each employee of The Jackson Laboratory that JAX ® Mice are so widely used—and so well respected—throughout the global research community; that our animal care, technical support, and other services are so highly regarded; and that our reputation as a research institution rem ains as exceptional as when the first Handbook was published in 1962. Am J Physiol 262(6 Pt 2):R1025-32, Whitehead GS; Walker JK; Berman KG; Foster WM; Schwartz DA. 1982. xmp.did:C6AD69875588E0119B65E91AE40D8D8E Two animals of the same strain and sex, aged 10 weeks, were introduced into a novel open-field for 10 min. 15 0 obj xmp.iid:c31c0f8a-1532-ed4d-a998-9ccad6f57fa8 ZERO BIAS - scores, article reviews, protocol conditions and more This large deletion apparently renders the protein incapable of providing resistance to influenza. Dietary obesity in nine inbred mouse strains. Overall, C57BL/6J mice breed well, are long-lived, and have a low susceptibility to tumors. Toggle menubar. 1992. (8). 1998. Mice derived from the original C57BL/6J: C57BL/ 6JArc, C57BL/6JfromThe Jackson Lab and C57BL/6J Physiol Genomics 5(4):205-15, Fontaine DA; Davis DB. Initial sequencing and comparative analysis of the mouse genome. .. SNP test showed that our IRAK-M−/− mice were fully back-crossed to B6 genetic background ( ). Skip to main content. Parabiosis requires the surgical joining of two mice by skin-to-skin anastomosis from the shoulder to the pelvic girdle. x�%�A�@�}O�(��'.�r�^���� Atherosclerosis and plasma and liver lipids in nine inbred strains of mice. J Lipid Res 32(4):559-68, Paigen B; Morrow A; Brandon C; Mitchell D; Holmes P. 1985. x�%�A�@�}O�(��'.�r�^���� <>stream Immunogenetics 61(3):199-207, Zurita E; Chagoyen M; Cantero M; Alonso R; Gonzalez-Neira A; Lopez-Jimenez A; Lopez-Moreno JA; Landel CP; Benitez J; Pazos F; Montoliu L. 2011. Diabetes 65(1):25-33, Ishida BY; Blanche PJ; Nichols AV; Yashar M; Paigen B. endstream It is near a spice acceptor site and causes a substantial decrease in expression at the mRNA and protein levels in homozygous brain, with additional decreases in Gabra1, Gabra3, and Gabra5 transcripts in striatum This allele can be phenoytpically reversed entirely by the correction of this intronic point deletion (see, Black BL; Croom J; Eisen EJ; Petro AE; Edwards CL; Surwit RS. Enter your email if you are happy for us to connect and reachout to you with more questions. Genome Res 14(9):1806-11, Roberts JE; Watters JW; Ballard JD; Dietrich WF. <>stream Both C57BL/6ByJ and C57BL/6NJ type as follows: 08-015199792-M (rs3709624) is C; 11-004367508-M (rs3659787) is A; 13-041017317-M (rs3722313) is C; 15-057561875-M (rs3702158) is G; 19-049914266-M (rs3724876) is T. C57BL/6J types as follows: 08-015199792-M (rs3709624) is T; 11-004367508-M (rs3659787) is G; 13-041017317-M (rs3722313) is T; 15-057561875-M (rs3702158) is A; 19-049914266-M (rs3724876) is G (Petkov and Wiles, 2004.) C57BL/6N mutation in Cytoplasmic FMRP interacting protein 2 regulates cocaine response. 6 0 obj from application/x-indesign to application/pdf The use and care of mice were approved by the Children’s Hospital of Philadelphia Research Institute Institutional Animal Care and Use Committee. 1�^���|7�PE$HG�cD�d�ҥ8C&���GӦmйM���u A{l��0�^aU[���"��֔���~%��6>��m 1995. It also maintains an integrated mouse information resource. Th ey are safe, reliable, economical, effi cient, and ensure that It is found in BALB/cAnCrl, BALB/cJ, C57BL/6Cr, C57BL/6JCrl, C57BL/6JOlaHsd, C57BL/6NCrl, C57BL/6NJcl, C57BL/6NHsd, C57BL/6NTac, C57BL/6NJ, B6(CG)-Tyr, This is spontaneous intronic single nucleotide deletion (a shortening of the homopolymer stretch of AAAA to AAA at Chr5:71,014,639-641 (GRCm38)). 1995. endstream C57BL/6J mice fed a high-fat diet develop obesity, mild to moderate hyperglycemia, and hyperinsulinemia (see JAX® Diet-induced Obesity (DIO) Models). 1�^���|7�PE$HG�cD�d�ҥ8C&���GӦmйM���u A{l��0�^aU[���"��֔���~%��6>��m Quantitative trait loci controlling allergen-induced airway hyperresponsiveness in inbred mice. Thus, colonization of mice with several defined bacterial species as well as with diverse microbiota from Jackson Laboratory B6 mice did not induce Th17 cell differentiation, in sharp contrast to the induction observed with bacteria from Th17 cell-sufficient Taconic Farms B6 mice … / A transgenic construct containing a 2.34 kb rat albumin enhancer/promoter, nuclear localization sequence-modified Cre recombinase and a 2.1 kb fragment from the human growth hormone gene was injected into B6D2(F2) pronuclei. Now over 200 generations from New York in 1920, BALB/c mice are distributed globally, and are among the most widely used inbred strains used in animal experimentation. 2000. endobj 1�^���|7�PE$HG�cD�d�ҥ8C&���GӦmйM���u A{l��0�^aU[���"��֔���~%��6>��m Adobe InDesign CC 2015 (Windows) 2004. Mamm Genome 10(11):1043-9, Bultman SJ; Klebig ML; Michaud EJ; Sweet HO; Davisson MT; Woychik RP. D2.APB Tg. These transactions are payable in U.S. currency within the granted terms. This variant is found in AKR/J, C3H/HeJ, C57BL/6, C57BL/10, CBA/J, DBA/1, DBA/2, FVB/NJ, and NZO/HILtJ. For more information, see the Worldwide Distributor List for JAX® Mice. endstream C57BL/6J mice are used in a wide variety of research areas including cardiovascular biology, developmental biology, diabetes and obesity, genetics, immunology, neurobiology, and sensorineural research. Resistance is expressed by macrophages and other cells in vitro (J:6649, J:5940) but could not be transferred to susceptible animals by transfer of macrophages from resistant mice (J:6149). Labeling: Article Title: IL … x�+� � | This strain is homozygous for Cdh23ahl, the age related hearing loss 1 mutation, which on this background results in progressive hearing loss with onset after 10 months of age. x�S�*�*T0T0 B�����i������ ye( Bioz Stars score: 92/100, based on 1 PubMed citations. rs216509331 SNP allele with the A variant. B6.Rag1-/- mice displayed nearly identical blood pressure increases monitored via radiotelemetry and hypertensive end-organ damage in response to different doses of Ang II and different levels of salt intake (0.02%, 0.3%, and 3% NaCl diet). Cx3cr1-EGFP mice (B6.129P-Cx3cr1tm1Litt /J, stock #005582), tdTomato mice [Gt(ROSA)26Sortm9(CAG-tdTomato)Hze , stock #007909], and Wnt1Cre mice [Tg(Wnt1-GAL4)11Rth, stock #003829] were from The Jackson Laboratory. 13 14 • Eyes are open • Pups begin to nibble solid food • Pups increase • Pups solid food intake in weight increase and size, eating more solid food . This deletion results in the absence of the NNT protein, and is associated with impaired glucose homeostasis control and reduced insulin secretion. x�+� � | proof:pdf Neuroscience 122(2):551-61, Mekada K; Abe K; Murakami A; Nakamura S; Nakata H; Moriwaki K; Obata Y; Yoshiki A. 1999. This is predicted to delete part of the 2nd and 3rd ectodomains and cause reduced message stability. One of the most used inbred mouse models, the C57BL/6 is used in nearly every research application, and it's commonly used as the genetic background for transgenic mouse models. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research. The protein is located in the nucleus (J:7703) and produces its antiviral effect by preventing synthesis of viral mRNA in the nucleus (J:7992). C57BL/6JOlaHsd Mice from Envigo (Harlan), Bicester, UK Deletion of Snca – no visible phenotype, but… Neurological Differences 22 Specht CG and Schoepfer R. 2001. It is the most widely used "genetic background" for genetically modified mice for use as models of human disease. J Am Assoc Lab Anim Sci 55(4):375-86, Paigen B. This model is perinatal lethal in homozygouse animals which die shortly after birth, presumably from breathing difficulties due … Transgenic Res 20(3):481-9. 16 0 obj JAX® Mice strains are only made available to researchers after meeting our standards. This allele confers 50% decreased plasma insulin at T30 during the intraperitoneal glucose tolerance test compared to C3H/HeH. This widely used … endobj default One of these, a C to T transition in exon 11 would change the arginine codon in the DBA/2J allele to an opal termination codon in the C57BL/6J allele. 24 0 obj These mice are on a D2 genetic background. endobj H��Wks�H��_�_��޲�EUH0�l\�lmu�܋Fj��_��v�����PSiK��x@��.^Ug����뙻��Dlq��?lx����E�z^.ăzz����w݀���{~u��&����p�S钌ɫ�F�Jԝl�#=W�� �Γ�e����F��:.쇒%.\L��M6�,�����F���#�ɜ�S� �Q@q�8�u�n�Z~K&k6uqc��Ҟ*��M�� ��b|�kY��Ǧmr��[��k>�a�����>�b��'����4^��(&�]6��O���lr�ej-X���h�MUI����%�� �y�7-~J�֟�\!d'��s���ل��u�����A(����KQ�Zt�Q�t(�8s�4H4�^��Qۍ����]*�7g{�LI�N��&%�r(�9F:B�x�G��+o�r[��w��k>f��ވ#�������`��Ԫ)�F�U���΢V����ߺA�O��pϼ�I�l�켘R��B�. Lipids 28(7):599-605, O'Malley J; Matesic LE; Zink MC; Strandberg JD; Mooney ML; De Maio A; Reeves RH. 1994. One of the unique advantages to working with mice, rather than other experimental organisms, is the availability of standard strains such as C57BL/6 (abbreviated B6), BALB/c, and many others that are used in thousands of laboratories around the world each year. Mice of the B6 background were the most susceptible to developing an abnormal IOP distribution, severe anterior segment developmental anomalies (including malformed eccentric pupils, iridocorneal strands, and corneal abnormalities) and glaucomatous nerve damage. The Mx genes determine resistance to the lethal effects of various myxoviruses including neurotropic avian influenza A virus injected intracerebrally, pneumotropic strains injected intranasally, and a hepatotropic strain injected intraperitoneally (J:5645, J:13136). Phenotype will meet all expectations deletion apparently renders the protein ( J:8273 ) Moody ;... C57Bl/6J strain-specific defect in neutrophil recruitment 11,000 strains of mice cholesterol diets in the mouse gene... Hydrocephaly than do other strains predicts a secreted protein ubiquitously expressed in mice with diet-induced atherosclerosis data! Is caused by a G to a transition at coding nucleotide position 753 of Cdh23 ( SNP rs257098870 ) alleles..., SWR of responsiveness to high-fat and high- cholesterol diets in the absence of the Nnt,. ( 12 ):5667-71, Welkos SL ; Keener TJ ; Gibbs PH care. Hybrid strains to noise-induced hearing loss causing frame skipping of exon 7 within KU without cost! Cernuda-Cernuda R ; Huerta JJ ; Munoz b6 mice jackson lab M ; Paigen B was found in,! Viral infection and in turn induces the Mx protein ( J:8273 ) for 10 min mice well! Lc ; Shiau YW ; Davis RR ; Krieg EF compound genotype created using this strain is the background... Frequency-Dependent tuning of LTP at hippocampal synapses of specific strains of mice inflammation mediated by T! Strain and background strain for the international collaboration that generated the first to have its ’ entire sequenced! Clade, which includes humans Pennsylvania Medical Center U.S. currency within the granted.! Mice carrying the lethal yellow mutation terms are granted by individual review and stated on the customer invoice ( )! Ahl that do not guarantee breeding performance and therefore suggest that investigators order than! And background strain is available from the shoulder to the C57L and C57BR strains,. A sequence variant is found in many inbred strains are maintained through sibling sister... And cause reduced message stability Mighty mice have been correlated with a point mutation in the production of mice. Hearing loss DM ; Millar SE ; Miller KA ; Barsh GS SN ; Young JZ Physiol Integr. Diet-Induced atherosclerosis hypomorphic allele changes splice donor site G-GT to A-GT, causing frame skipping exon., Paigen B J Immunol 129 ( 4 ):1530-3, Smith BK ; Andrews PK ; DB... Susceptible to diet-induced obesity ):1508-12, McKhann GM 2nd ; Wenzel HJ Robbins. A high affinity, relatively heat stabile, 95 kDa receptor 7-11 occurred in mice! ; Morrow a ; Brandon C ; Mitchell D ; Holmes P. 1985 for more information, see the Distributor. Efficient SNP system for mouse genome J:7365 ) in cytoplasmic FMRP interacting protein 2 regulates cocaine.. By skin-to-skin anastomosis from the Jackson Laboratory Resource Manual Th is Manual describes breeding and...: 129S1/SvImJ, C3H/HeSnJ, I/LnJ, YBR/Ei, 020/A, 129/J, SF/CamEi and SK/CamEi many strains. ( B6 ), the phenotype of each strain may not be fully characterized and/or captured in shared., Welkos SL ; Keener TJ ; Gibbs PH D ; Holmes 1985. Lab stock # 034832 ( formerly as Jackson Lab stock # 034832 ( formerly as Jackson Lab stock 000664. Melatonin production in C57BL/6J ( T ) as compared to DBA/2J cross circulation is established in two to days! Became less than * 12 cm glucose Intolerance in C57BL/6J ( T ) as compared to C57BL/6N ( )! Currency within the granted terms aged C57BL/6J males and females between 25 - weeks. ):1806-11, Roberts JE ; Watters JW ; Ballard JD ; WF... Origin - this allele was found in C57BL/6J and C57BL/6N mouse strains generation! ; Munoz Llamosas M ; Paigen B and C3HeB/FeJ mice ( Mus musculus ) SNPs were found informative to among. Shown allelism between the centers of the Laboratory mouse is an albino, laboratory-bred strain of origin this! Hybrid strains to noise-induced hearing loss the study of impaired glucose homeostasis control in C57BL/6J mice approved... To C3H/HeH reversal of diet-induced obesity and diabetes in C57BL/6J mice 92/100, on... For some deleterious mutations used research strain to the availability of congenic strains, easy breeding, and robustness performance... Demonstrated cDNA corresponding to exons b6 mice jackson lab occurred in C57BL/6J mice were mated to CAST, and hippocampal.... At C57BL/6 background and housed in the C57BL/6J mouse model of age-related hearing.! Low and high fat diets for the generation of congenics carrying both and. By the Jackson Laboratory at F32 tumors, it is the most widely used `` genetic background informative discriminate. Mutation include: 129S1/SvImJ, C3H/HeSnJ, I/LnJ, YBR/Ei, 020/A, 129/J, SF/CamEi and SK/CamEi have pups... Using the B6 mouse strain, due to the transgene Physiol 285 ( 1 ),... 20 ± 2 °C, with food and water ad libitum DNA source for the international collaboration that generated first... Strain of origin - this allele contains a stretch of 17,814 bp missing between exons 6 and 12 and! Tolerance test compared to C3H/HeH sensitivity, seizure behavior, mortality, and then, these exhibit! Of melatonin production in C57BL/6J ( 000664 ) mice °C, with food and water ad libitum affinity, heat! Backcrossed and maintained at C57BL/6 background and housed in the mouse strains C57BL/6 and C3H, Sarna ;... Their research 7-11 occurred in C57BL/6J mice 14 ( 9 ):1806-11, Roberts JE ; Watters JW Ballard! Nishina PM ; Verstuyft J ; Astle cm ; Harrison DE B6 mice were by... Agouti gene hippocampal synapses of specific strains of mice general purpose strain and sex, aged 10 weeks, introduced! Reference strain a 16 h light-8 h dark cycle, at 20 ± 2 °C, with food and ad! Mother of the Laboratory mouse genome complement receptor-bearing B lymphocytes normal mice that possess the for. Balb/C is an albino, agouti, and atherosclerosis allergen-induced airway hyperresponsiveness in inbred mice 3,222,537 ( )... Including C57BL/6J, C57BL/10, and robustness ( FV ) et al., )... Complement receptor-bearing B lymphocytes 47 ( 9 ):1089-96, Parham K. 1997 disease! ; Roderick Th ; Sundberg JP as JAX MMRRC stock # 034832 ( formerly Jackson. Wound healing and cross circulation is established in two to three days genes Dev 8 ( 4 ),... ; Duhl DM ; Millar SE ; Miller KA ; Barsh GS were! 3 ):795-800, West DB in two to three days JAX MMRRC stock # 034832 ( as! First to have more pups with hydrocephaly than do other strains approved the... And comparative analysis of C57BL/6J “ Eve ”, the most commonly used b6 mice jackson lab a background for maximal of. At position 3,222,537 ( GRCm38 ) and background strain for the study of in! Is dependent on the presence of interferon-alpha and -beta but not -gamma ( )... Sosunov AA ; Schwartzkroin PA. 2003 to researchers after meeting our standards Philadelphia research Institute Institutional Animal care use... Aa ; Schwartzkroin PA. 2003 well characterized, the Nnt protein, and ensure that the strains. Miss Abby Lathrop ’ s stock that also gave rise to strains C57BR and.. Mutation in cytoplasmic FMRP interacting protein 2 regulates cocaine response P. 1985 Cernuda-Cernuda ;!, are long-lived, and NZO/HILtJ Accounting for glucose Intolerance in C57BL/6J mice, seizure,... Phenotype of each strain may not be fully characterized and/or captured in the shared quest improve... Mice search water ad libitum to high-fat and high- cholesterol diets in the of! And 12 hoping to find what you were looking for Physiol 285 ( 1 ),... Predicted to delete part of the 2nd and 3rd ectodomains and cause reduced message stability 1-death and. The Laboratory mouse C3HeB/FeJ mice ( Mus musculus ) of human disease efficient SNP system for genome! Surwit RS 91 ( 12 ):5667-71, Welkos SL ; Keener TJ Gibbs. ; Duffy SN ; Young JZ strain in a publication, please include JAX stock # 000664 in Materials! Chen J ; Astle cm ; Harrison DE breeding strategies and techniques for maintaining colonies Laboratory. Loci determining bone density among inbred strains of mice plasma lipoproteins in the shared quest to human... 113 ( 5 ):2484-93, Nishina PM ; Verstuyft J ; Paigen B ; Morrow a ; Brandon ;... D ; Benoist C. 2016 phenotypic and genomic analysis of the mouse agouti gene predicts a secreted protein ubiquitously in. Pair to avoid delays in their research have shown allelism between the mdfw ( modifier of waddler... Of normal mice that possess the gene encoding arylalkylamine N-acetyltransferase joining of two mice by skin-to-skin anastomosis from the to. 1951 from the Jackson Laboratory at F32 C57BL/6J was the DNA source the..., McKhann GM 2nd ; Wenzel HJ ; Robbins CA ; Sosunov AA ; Schwartzkroin PA. 2003 missing between 6! Genotype created using this strain ):5667-71, Welkos SL ; Keener TJ ; Gibbs b6 mice jackson lab ubiquitously expressed mice... Worldwide Distributor List for JAX® mice resistance to influenza of Miss Abby Lathrop ’ s stock that gave! The assays used partially purified DNA as described in Paigen et al of impaired glucose homeostasis control reduced. The first high quality draft sequence of the developmental stages of albino, laboratory-bred strain of the protein... S a 113 ( 5 ):1345-50, Erway LC ; Shiau YW ; Davis ;... ( J:6265 ) that generated the first high quality draft sequence of the males JAX MMRRC stock 034832. Quantitive trait locus Accounting for glucose Intolerance in C57BL/6J mice show greatly delayed senescence relative to BALB/c and DBA/2J is. Rr ; Krieg EF strain and the first to have its ’ entire sequenced... ) breeding facilities in Japan and/or Europe the centers of the 2nd and 3rd ectodomains and cause message. In Paigen et al B6 ) mice have shown allelism between the centers of the.... Mice show greatly delayed senescence relative to BALB/c and DBA/2J the transgene the genetic background reduced message stability,! ; Astle cm ; Harrison DE cell 71 ( 7 ):1195-204, Cernuda-Cernuda R ; JJ! Genetic heterogeneity of plasma lipoproteins in the special pathogen-free facilities b6 mice jackson lab use as models human...