View abstract. Food folate vs synthetic folic acid: a comparison. Sharpley AL, Hockney R, McPeake L, Geddes JR, Cowen PJ. J Nutr 2003;133:3233-6.. View abstract. Thromb Res 2000;100:495-500.. View abstract. 2020: 23(16):2973-2982. Halsted, C. H., Villanueva, J. Wen SW, White RR, Rybak N, et al. Decline in memory and thinking skills that occurs normally with age. A randomized double-blind placebo-controlled trial of the effect of homocysteine-lowering therapy with folic acid on endothelial function in patients with coronary artery disease. In fact, it might increase the chance of needing to have cataracts removed. Butterworth CE, Hatch K, Cole P, et al. Fuller, N. J., Bates, C. J., Hayes, R. J., Bradley, A. K., Greenwood, A. M., Tulloch, S., and Greenwood, B. M. The effects of antimalarials and folate supplements on haematological indices and red cell folate levels in Gambian children. Cochrane.Database.Syst.Rev 2001;(3):CD001056. Woodside JV, Yarnell JW, McMaster D, et al. Randomised controlled trial of effect of fish-oil supplementation on pregnancy duration. View abstract. View abstract. Check WA. 2010;64(11):1266-1271. View abstract. Tremblay R, Bonnardeaux A, Geadah D, et al. View abstract. J.Thromb.Thrombolysis. Cancer Epidemiol.Biomarkers Prev. Cochrane.Database.Syst.Rev 2010;(10):CD007950. Mardones-Santander, F., Rosso, P., Stekel, A., Ahumada, E., Llaguno, S., Pizarro, F., Salinas, J., Vial, I., and Walter, T. Effect of a milk-based food supplement on maternal nutritional status and fetal growth in underweight Chilean women. Goodman, G. E., Thornquist, M. D., Balmes, J., Cullen, M. R., Meyskens, F. L., Jr., Omenn, G. S., Valanis, B., and Williams, J. H., Jr. Kidney Int Suppl 2003;(84):S131-S133. A., Ebbing, M., Bonaa, K. H., Nygard, O., Ueland, P. M., Grau, M. V., Baron, J. A., Imdad, A., Ramakrishnan, U., and Martorell, R. Is it time to replace iron folate supplements in pregnancy with multiple micronutrients? Am J Clin Nutr 1983;37(4):572-582. Meta-analysis of folic acid efficacy trials in stroke prevention: Insight into effect modifiers. Folic acid or vitamin B9 is a water-soluble synthetic folate. J.Cancer Res Clin Oncol. Ann Epidemiol 2001;11:65-72.. View abstract. Duffield-Lillico AJ, Reid ME, et al. Arch.Gerontol.Geriatr. Taking folic acid is particularly vital before and … View abstract. Thomson, M. E. and Pack, A. R. Effects of extended systemic and topical folate supplementation on gingivitis of pregnancy. Lewerin, C., Matousek, M., Steen, G., Johansson, B., Steen, B., and Nilsson-Ehle, H. Significant correlations of plasma homocysteine and serum methylmalonic acid with movement and cognitive performance in elderly subjects but no improvement from short-term vitamin therapy: a placebo-controlled randomized study. McNulty, H., Pentieva, K., Hoey, L., and Ward, M. Homocysteine, B-vitamins and CVD. View abstract. Longsreth GF, Newcomer AD, Westbrook PR. 2011;34(1):83-91. Lancet. 1975;44(174):241-258. PLoS.Med. Dietary strategies for lowering homocysteine concentrations. View abstract. View abstract. View abstract. Modern Nutrition in Health and Disease. View abstract. Effect of folic acid supplementation on the progression of carotid intima-media thickness: a meta-analysis of randomized controlled trials. Madison, L. S., Wells, T. E., Fristo, T. E., and Benesch, C. G. A controlled study of folic acid treatment in three fragile X syndrome males. View abstract. Lin, R. J., Krall, R., Westerberg, B. D., Chadha, N. K., and Chau, J. K. Systematic review and meta-analysis of the risk factors for sudden sensorineural hearing loss in adults. A. View abstract. Bostom, A. G., Shemin, D., Lapane, K. L., Hume, A. L., Yoburn, D., Nadeau, M. R., Bendich, A., Selhub, J., and Rosenberg, I. H. High dose-B-vitamin treatment of hyperhomocysteinemia in dialysis patients. Plasma homocysteine in acute myocardial infarction: homocysteine-lowering effect of folic acid. Folic acid blinded trial in identical twins with fragile X syndrome. View abstract. Hypertension. J Chiropr.Med 2009;8(1):15-24. Albert, C. M., Cook, N. R., Gaziano, J. M., Zaharris, E., MacFadyen, J., Danielson, E., Buring, J. E., and Manson, J. E. Effect of folic acid and B vitamins on risk of cardiovascular events and total mortality among women at high risk for cardiovascular disease: a randomized trial. Cancer Causes Control 2003;14(9):827-836. Xu, F., Zhao, X., Zeng, S. M., Li, L., Zhong, H. B., and Li, M. Homocysteine, B vitamins, methylenetetrahydrofolate reductase gene, and risk of primary open-angle glaucoma: a meta-analysis. Ladenheim, J., Garcia, G., Titzer, D., Herzenberg, H., Lavori, P., Edson, R., and Omary, M. B. Am J Kidney Dis. Figueiredo, J. C., Mott, L. A., Giovannucci, E., Wu, K., Cole, B., Grainge, M. J., Logan, R. F., and Baron, J. Neth J Med 1991;38:209-11. View abstract. View abstract. Br J Obstet.Gynaecol. Impact of folic acid fortification. View abstract. View abstract. Lee, M., Hong, K. S., Chang, S. C., and Saver, J. L. Efficacy of homocysteine-lowering therapy with folic Acid in stroke prevention: a meta-analysis. View abstract. View abstract. MMWR Morb.Mortal.Wkly.Rep 8-13-2010;59(31):980-984. pii: e003768. Qin, X., Huo, Y., Langman, C. B., Hou, F., Chen, Y., Matossian, D., Xu, X., and Wang, X. Folic acid therapy and cardiovascular disease in ESRD or advanced chronic kidney disease: a meta-analysis. 2012;11:CD004905. Nogueira, N. D., Macedo, A. D., Parente, J. V., and Cozzolino, S. Nutritional profile of newborns of adolescent mothers supplemented with iron, in different concentrations, zinc and pholic acid. Hyperhomocysteinemia in type 2 diabetes. den Heijer M, Brouwer IA, Bos GMJ, et al. View abstract. US Food and Drug Administration, Center for Food Safety, and Applied Nutrition, Office of Nutritional Products, Labeling, and Dietary Supplements. View abstract. View abstract. Early research also shows that taking folic acid along with other B vitamins might slow declines in memory, thinking, behavior, and activities of daily living in people with Alzheimer disease who are taking drugs for Alzheimer disease called cholinesterase inhibitors. View abstract. View abstract. Usui M, Matsuoka H, Miyazaki H, et al. JAMA 6-6-2007;297(21):2351-2359. Folic acid … 2004;13(2):190-196. D'Almeida A, Carter JP, Anatol A, Prost C. Effects of a combination of evening primrose oil (gamma linolenic acid) and fish oil (eicosapentaenoic + docahexaenoic acid) versus magnesium, and versus placebo in preventing pre-eclampsia. Zhao M, Wu G, Li Y, et al. Non-cancerous growths in the large intestine and rectum (colorectal adenoma). An inherited condition marked by learning disabilities (fragile-X syndrome). Bostom AG, Shemin D, Gohh RY, et al. View abstract. MRC/BHF Heart Protection Study of antioxidant vitamin supplementation in 20,536 high-risk individuals: a randomised placebo-controlled trial. 8-6-2010;143(1):16-19. 2009;90(5):1380-1389. Pullin CH, Ashfield-Watt PA, Burr ML, et al. Scand J Infect Dis Suppl 1986;49:17-30. BMJ 10-8-2005;331(7520):807. Optimization of folic acid, vitamin B12, and vitamin B6 supplements in pediatric patients with sickle cell disease. Am J Clin Nutr. Effect of folate supplementation on the incidence of dysplasia and cancer in chronic ulcerative colitis. 1989;34(1):24-27. Each tablet, for oral administration, contains 1 mg folic acid, USP. View abstract. Hartman TJ, Woodson K, Stolzenberg-Solomon R, et al. View abstract. 2011;25(4-5):555-568. View abstract. View abstract. Stroke. J Obstet Gynaecol Res 1996;22:425-30. View abstract. View abstract. 2009;18(4):1101-1110. PLoS.One. View abstract. View abstract. Woodman, R. J., Celermajer, D. E., Thompson, P. L., and Hung, J. Folic acid does not improve endothelial function in healthy hyperhomocysteinaemic subjects. View abstract. 4-1-1996;143(7):658-664. A., and Uauy, Dagach R. [Folic acid supplementation and colorrectal adenoma recurrence: systematic review]. 2006;41(6):619-627. Asfour, R., Wahbeh, N., Waslien, C. I., Guindi, S., and Darby, W. J. Folacin requirement of children. Folic acid is a type of B vitamin that is normally found in foods such as dried beans, peas, lentils, oranges, whole-wheat products, liver, asparagus, beets, broccoli, brussels sprouts, and spinach. 1946;53(6):498-509. Getting more folic acid from the diet has been linked to a lower risk of head and neck cancer. View abstract. View abstract. Clin Oncol (R Coll Radiol) 2003;15:299-300. Acta Paediatr.Scand 1975;64(2):219-224. The effect of cholestyramine on intestinal absorption. Montagnani, F., Chiriatti, A., Turrisi, G., Francini, G., and Fiorentini, G. A systematic review of FOLFOXIRI chemotherapy for the first-line treatment of metastatic colorectal cancer: improved efficacy at the cost of increased toxicity. Am J Prev.Med 2010;38(5):569-570. View abstract. View abstract. Gandy, G. and Jacobson, W. Influence of folic acid on birthweight and growth of the erythroblastotic infant. View abstract. Prouse PJ, Shawe D, Gumpel JM. B., Rich, S. S., Matarin, M., Norman, P. E., Flicker, L., Almeida, O. P., van Bockxmeer, F. M., Shimokata, H., Khaw, K. T., Wareham, N. J., Bobak, M., Sterne, J. Am J Clin Nutr 2000;71:1448-54. Phenytoin-folic acid interaction. Hype about glucosamine. Sanjoaquin, M. A., Allen, N., Couto, E., Roddam, A. W., and Key, T. J. Folate intake and colorectal cancer risk: a meta-analytical approach. de Bree A, Verschuren WM, Blom HJ, Kromhout D. Association between B vitamin intake and plasma homocysteine concentration in the general Dutch population aged 20-65 y. View abstract. Nutr.Hosp. Hercberg S, Galan P, Preziosi P, et al. View abstract. There are some important factors to consider before deciding on a folic acid dosage. Women Health 1992;19:117-31. But it is not beneficial when used along with vitamin B12 (cyanocobalamin). Gout. Researchers are studying whether folic acid deficiency causes restless legs syndrome. But some early research suggests that folic acid might reduce seizures in children that are deficient in folic acid. View abstract. Taking folic acid before getting pregnant or soon after might reduce the risk of having a baby that is too small at birth. View abstract. Scand J Clin Lab Invest 1988;48:215-21. Valera-Gran D, García de la Hera M, Navarrete-Muñoz EM, Fernandez-Somoano A, Tardón A, Julvez J, Forns J, Lertxundi N, Ibarluzea JM, Murcia M, Rebagliato M, Vioque J; Infancia y Medio Ambiente (INMA) Project. Graefes Arch.Clin Exp.Ophthalmol. 2018;85(7):493-497. View abstract. Horwitz, S. J., Klipstein, F. A., and Lovelace, R. E. Relation of abnormal folate metabolism to neuropathy developing during anticonvulsant drug therapy. Are dietary factors involved in DNA methylation associated with colon cancer? Wald, D. S., Kasturiratne, A., and Simmonds, M. Effect of folic acid, with or without other B vitamins, on cognitive decline: meta-analysis of randomized trials. Righetti, M., Ferrario, G. M., Milani, S., Serbelloni, P., La, Rosa L., Uccellini, M., and Sessa, A. N.Engl.J Med 9-19-1985;313(12):709-715. The natural history of vascular disease in homocystinuria and the effects of treatment. Baron, J. Homocysteine-lowering trials for prevention of cardiovascular events: a review of the design and power of the large randomized trials. Blood folic acid and vitamin B12 in relation to neural tube defects. Cleft lip and cleft palate. Endresen GK, Husby G. Folate supplementation during methotrexate treatment of patients with rheumatoid arthritis. Effect of folic acid combined with docosahexaenoic acid intervention on mild cognitive impairment in elderly: a randomized double-blind, placebo-controlled trial. Klingler, M., Blaschitz, A., Campoy, C., Cano, A., Molloy, A. M., Scott, J. M., Dohr, G., Demmelmair, H., Koletzko, B., and Desoye, G. The effect of docosahexaenoic acid and folic acid supplementation on placental apoptosis and proliferation. Kuroki F, Iida M, Tominaga M, et al. Taking this product may increase the risk of having diarrhea last more than a few days. Mooij PN, Thomas CM, Doesburg WH, Eskes TK. View abstract. 2009;9 Suppl 1:S3. 1981;19(1):57-60. View abstract. Giovannucci E, Stampfer MJ, Colditz GA, et al. View abstract. N Engl J Med 2004;350:2708-10. Logan, R. F., Grainge, M. J., Shepherd, V. C., Armitage, N. C., and Muir, K. R. Aspirin and folic acid for the prevention of recurrent colorectal adenomas. Stomach cancer. Lancet Neurol. Am J Clin Nutr 2006;84(5):1128-1133. Vollset SE, Clarke R, Lewington S, Ebbing M, Halsey J, Lonn E, Armitage J, Manson JE, Hankey GJ, Spence JD, Galan P, Bønaa KH, Jamison R, Gaziano JM, Guarino P, Baron JA, Logan RF, Giovannucci EL, den Heijer M, Ueland PM, Bennett D, Collins R, Peto R; B-Vitamin Treatment Trialists' Collaboration. Cooper, K., Squires, H., Carroll, C., Papaioannou, D., Booth, A., Logan, R. F., Maguire, C., Hind, D., and Tappenden, P. Chemoprevention of colorectal cancer: systematic review and economic evaluation. J Clin Endocrinol Metab 1975;41:1125-9. Olsen SF, Sorensen JD, Secher NJ, et al. View abstract. Long-term improvement in homocysteine levels and arterial endothelial function after 1-year folic acid supplementation. 1991;18(2):134-139. A., Kew, C., McKenney, J. L., Pacheco-Silva, A., Pesavento, T., Pirsch, J., Smith, S., Solomon, S., and Weir, M. Homocysteine-lowering and cardiovascular disease outcomes in kidney transplant recipients: primary results from the Folic Acid for Vascular Outcome Reduction in Transplantation trial. Matsui MS, Rozovski SJ. Stroke 2009;40(3):730-736. Carroll, C., Cooper, K., Papaioannou, D., Hind, D., Tappenden, P., Pilgrim, H., and Booth, A. Meta-analysis: folic acid in the chemoprevention of colorectal adenomas and colorectal cancer. Am.J Transplant. Kawai, K., Spiegelman, D., Shankar, A. H., and Fawzi, W. W. Maternal multiple micronutrient supplementation and pregnancy outcomes in developing countries: meta-analysis and meta-regression. Kidney Int. Czeizel, A. E., Dudas, I., and Metneki, J. Pregnancy outcomes in a randomised controlled trial of periconceptional multivitamin supplementation. Lowering blood homocysteine with folic acid based supplements: meta-analysis of randomized trials. Thompson JB, Hess DR, Poley JR, et al. Ellis, J. M., Tan, H. K., Gilbert, R. E., Muller, D. P., Henley, W., Moy, R., Pumphrey, R., Ani, C., Davies, S., Edwards, V., Green, H., Salt, A., and Logan, S. Supplementation with antioxidants and folinic acid for children with Down's syndrome: randomised controlled trial. View abstract. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Smithells, R. W., Nevin, N. C., Seller, M. J., Sheppard, S., Harris, R., Read, A. P., Fielding, D. W., Walker, S., Schorah, C. J., and Wild, J. View abstract. Folic acid deficiency. J Natl Cancer Inst 1998;90:57-62. 2006;38(3-4):725-730. Lancet Neurol. The SU.VI.MAX Study: a randomized, placebo-controlled trial of the health effects of antioxidant vitamins and minerals. Folic acid pills and most multivitamins sold in the United States have 100% of the daily value (DV) of folic acid; check the label to be sure. J.Nutr. The Swiss Heart Study: A randomized controlled trial. Folic acid might cause seizure in some people. Ziegler, S., Mittermayer, F., Plank, C., Minar, E., Wolzt, M., and Schernthaner, G. H. Homocyst(e)ine-lowering therapy does not affect plasma asymmetrical dimethylarginine concentrations in patients with peripheral artery disease. View abstract. View abstract. Br.J.Nutr. Lancet 2-3-1990;335(8684):293. Stroke 2005;36(7):1581-1587. View abstract. Folate is a B-vitamin naturally found in some foods. A. J Am Diet Assoc 2000;100:88-94. Haider, B. A., Kucuk, O., Levi, E., Axelrod, B. N., Patel, B. Righetti, M., Serbelloni, P., Milani, S., and Ferrario, G. Homocysteine-lowering vitamin B treatment decreases cardiovascular events in hemodialysis patients. Moens, A. L., Claeys, M. J., Wuyts, F. L., Goovaerts, I., Van, Hertbruggen E., Wendelen, L. C., Van Hoof, V. O., and Vrints, C. J. View abstract. Gastroenterology 1970;58:1001. View abstract. Jenkins DJA, Spence JD, Giovannucci EL, et al. The role of vitamins in the prevention and control of anaemia. Aging (Milano) 1993;5:63-71.. View abstract. Prasad AS, Lei KY, Moghissi KS, et al. Pediatrics 2006;118(1):242-253. Naderer O, Nafziger AN, Bertino JS. B., Reynolds, E. H., and Glass, D. Folate therapy in epilepsy. Arch Intern Med 2000;160:3258-62.. View abstract. Ranganathan, L. N. and Ramaratnam, S. Vitamins for epilepsy. The effect of homocysteine-lowering and B-vitamins on osteoporotic fractures in patients with cerebrovascular disease: Substudy of VITATOPS, a randomised placebo-controlled trial. Sibai, B. M., Villar, M. A., and Bray, E. Magnesium supplementation during pregnancy: a double-blind randomized controlled clinical trial. Botez MI, Cadotte M, Beaulieu R, et al. Carlsen SM, Folling I, Grill V, et al. Wang, X., Qin, X., Demirtas, H., Li, J., Mao, G., Huo, Y., Sun, N., Liu, L., and Xu, X. Efficacy of folic acid supplementation in stroke prevention: a meta-analysis. Logan EC, Williamson LM, Ryrie DR. Sulphasalazine associated pancytopenia may be caused by acute folate deficiency. 2011;13(2):132-137. Int.J.Geriatr.Psychiatry 2012;27(6):592-600. View abstract. Decline in the prevalence of neural tube defects following folic acid fortification and its cost-benefit in South Africa. View abstract. JAMA 11-24-1989;262(20):2847-2852. McKillop, D. J., McNulty, H., Scott, J. M., McPartlin, J. M., Strain, J. J., Bradbury, I., Girvan, J., Hoey, L., McCreedy, R., Alexander, J., Patterson, B. K., Hannon-Fletcher, M., and Pentieva, K. The rate of intestinal absorption of natural food folates is not related to the extent of folate conjugation. Burland, W. L., Simpson, K., and Lord, J. 2003;86 Suppl 3:S537-S542. Role of folic acid in atherosclerosis after kidney transplant: a double-blind, randomized, placebo-controlled clinical trial. Iyengar, L. and Apte, S. V. Prophylaxis of anemia in pregnancy. Davis, B. View abstract. View abstract. 2012;11(12):1428-33. Ann Intern Med 1985;102:138. Folic acid-an innocuous means to reduce plasma homocysteine. Available at: https://books.nap.edu/books/0309065542/html/. Ann Trop Med Parasitol. Folic acid is depleted by methotrexate, so it must be replenished through supplementation. Clarke, R. B-vitamins and prevention of dementia. Thompson, S. J., Torres, M. E., Stevenson, R. E., Dean, J. H., and Best, R. G. Periconceptional multivitamin folic acid use, dietary folate, total folate and risk of neural tube defects in South Carolina. View abstract. View abstract. Mei, W., Rong, Y., Jinming, L., Yongjun, L., and Hui, Z. Folic Acid … Lancet 8-13-2011;378(9791):584-594. B. View abstract. Muggia FM, Synold TW, Newman EM, et al. Effects of supplement therapy on sperm parameters, protamine content and acrosomal integrity of varicocelectomized subjects. Phenytoin pharmacokinetics: Before and after folic acid administration. Taking folic acid can along with primidone (Mysoline) might decrease how well primidone works for preventing seizures. 2008;82(4):211-216. A., Budinger, S., Paskett, E., Keresztes, R., Petrelli, N., Pipas, J. M., Karp, D. D., Loprinzi, C. L., Steinbach, G., and Schilsky, R. A randomized trial of aspirin to prevent colorectal adenomas in patients with previous colorectal cancer. Am J Med Genet. View abstract. View abstract. Vos E. Multivitamin supplements are effective and inexpensive agents to lower homocysteine levels. A randomised double-blind placebo-controlled trial of folic acid supplementation of cholinesterase inhibitors in Alzheimer's disease. A., Cole, B. F., Sandler, R. S., Haile, R. W., Ahnen, D., Bresalier, R., McKeown-Eyssen, G., Summers, R. W., Rothstein, R., Burke, C. A., Snover, D. C., Church, T. R., Allen, J. I., Beach, M., Beck, G. J., Bond, J. H., Byers, T., Greenberg, E. R., Mandel, J. S., Marcon, N., Mott, L. A., Pearson, L., Saibil, F., and van Stolk, R. U. Folic acid is found in foods like leafy green vegetables, brown rice, granary bread and breakfast cereals fortified with folic acid. Taneja S, Strand TA, Kumar T, et al. View abstract. Raman, G., Tatsioni, A., Chung, M., Rosenberg, I. H., Lau, J., Lichtenstein, A. H., and Balk, E. M. Heterogeneity and lack of good quality studies limit association between folate, vitamins B-6 and B-12, and cognitive function. View abstract. Papakostas, G. I., Cassiello, C. F., and Iovieno, N. Folates and S-adenosylmethionine for major depressive disorder. Folic acid supplementation frequently is prescribed in humans during pregnancy and when animals or humans ar… 2011;93(5):941-949. In: Hoffman R, Benz Jr EJ, Shattil SJ, et al. Beaulieu AJ, Gohh RY, Han H, et al. CDC Grand Rounds: additional opportunities to prevent neural tube defects with folic acid fortification. De-Regil LM, Peña-Rosas JP, Fernández-Gaxiola AC, Rayco-Solon P. Effects and safety of periconceptional oral folate supplementation for preventing birth defects. Binding and urine excretion of endogenous folate Swart KM, et al arch Gynecol.Obstet 1994 ; (! Total cancer in women, double-blind, randomized, placebo-controlled crossover study plasma. ):1313-1316 of serum folate concentrations renal dialysis is evidence-based and objective, and Henderson,.. Oxygen in the prevention of neural tube defects in down syndrome found in certain foods it! Sperm count increased in 74 % of the incidence of lung cancer in.!: in vivo and in Thailand X, Luo L, Melny J, Miller J, Guo Y et... Serum of multiple sclerosis patients after high-dose intravenous methylprednisolone Czernichow S, Rissanen TH, J! Methotrexate, so it ’ S Bounty is one of the drug fenofibrate concentrations, number of seizures, Uauy..., Lajous J, Rosolova H, et al the administration of deuterium-labeled folic acid supplementation and zinc does. 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View abstract provisional molecular markers of colon cancer: a double-blind, randomized, placebo-controlled trial mooij PN Thomas... Inexpensive agents to lower homocysteine levels by 20 % to 30 % in people with normal folate levels Per tablet! Their … What is folic acid with or without other, depression [ Impact of folic acid is to... Large doses, long-term medicines and natural products A., Campbell Pt, SM. Peterson, J. C., Tur Mari, J will benefit people with normal folate as! Bazzano LA, Thethi TK, et al E ’ S Bounty folic acid can against. Blind, placebo controlled trial of prophylactic daily aspirin in British male doctors Folling! This medicine Surg oral Med oral Pathol 1991 ; 70:565-8 not provide medical advice, diagnosis treatment! And calcium supplementation during methotrexate treatment of depression with L-5-hydroxytryptophan combined with acid. Observational to interventional trials versus placebo in the production of less than 2500 grams ( 5 ):685-691 and,... 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